ACSC may refer to:
Advanced Casino Systems Corporation, a product group of Bally Technologies Air Command and Staff College, Montgomery, Alabama Alternating Closed and Semi-Closed rebreather, a special type rebreather for diving Ambulatory care sensitive conditions, a category of illnesses or health conditions Anderson Community School Corporation, Anderson, Indiana Asheville City SC, a National Premier Soccer League club based in Asheville, North Carolina Australian Command and Staff College, Weston Creek, Canberra Australian Cyber Security Centre Automobile Club of Southern California