Grape Island may refer to
Grape Island (West Virginia), in the Ohio River Grape Island, West Virginia, an unincorporated community in Pleasants County, West Virginia Grape Island (Lake Michigan), part of the Beaver Island (Lake Michigan) archipelago Grape Island (Norfolk County, Massachusetts), one of the Boston Harbor Islands Grape Island (Essex County, Massachusetts), Plum Island Sound, Ipswich, Massachusetts Grape Island (Lake Simcoe), Ontario, Canada