Mike or Michael Griffin may refer to:
Public officials Michael Griffin (Wisconsin politician) (1842–1899), Irish-born American congressman Michael D. Griffin (born 1949), American physicist, NASA administrator and Under Secretary of Defense Michael Griffin (Indiana politician), American state senator in 2022
Sportsmen Mike Griffin (outfielder) (1865–1908), American baseball manager for Brooklyn Bridegrooms Michael Griffin (footballer) (1886–1923), English striker Mike Griffin (basketball) (born 1943), American coach at Rensselaer Polytechnic Institute Mike Griffin (pitcher) (born 1957), American pitching coach for Norfolk Tides Michael Griffin (American football) (born 1985), safety for NFL Tennessee Titans Michael Griffin II (born 1998), American gridiron football defensive back
Others Michael Griffin (Irish priest) (1892–1920), victim of fatal shooting during Irish War of Independence Michael Griffin (surgeon) (born 1955), British clinical researcher in early cancer diagnosis Michael Griffin (escape artist) (born 1961), American magician and illusionist Michael F. Griffin (born 1962), American convicted for Murder of David Gunn