Issel is an Italian surname, and the name of a town in France. It can refer to:
Places Oude IJssel, river in Germany and the Netherlands Issel, Aude, France
People Saint Issel, 6th-century Welsh saint Alberto Issel (1848–1926), Italian painter Arturo Issel (1842–1922), Italian geologist and malacologist Dan Issel (born 1948), American basketball player Kim Issel (born 1967), Canadian ice hockey right winger Germán Issel (born 1986), Argentinian entrepreneur