The second season of the American television medical drama Grey's Anatomy commenced airing on the American Broadcasting Company (ABC) channel on September 25, 2005, and concluded on May 15, 2006. Shonda Rhimes was the series' showrunner and executive producer. Actors Ellen Pompeo, Sandra Oh, Katherine Heigl, Justin Chambers, and T. R. Knight reprised their roles as surgical interns Meredith Grey, Cristina Yang, Izzie Stevens, Alex Karev, and George O'Malley respectively. Previous main cast members Chandra Wilson, James Pickens Jr., Isaiah Washington and Patrick Dempsey also returned, while Kate Walsh, who began the season in a recurring capacity, was promoted to series-regular status.

The season continued to focus on the surgical residency of five young interns as they try to balance the challenges of their competitive careers with difficulties in their personal lives. It was set in the fictional Seattle Grace Hospital, located in the city of Seattle, Washington. Whereas the first season put the emphasis mainly on the unexpected impact the surgical field has on the main characters, the second season provided a detailed perspective on the personal background of each character, focusing on the consequences that their decisions have on their careers. Throughout the season new storylines were introduced, including the love-triangle between Meredith Grey, Derek Shepherd, and Addison Montgomery, this being the main arc of the season. Also heavily developed was the storyline involving Izzie Stevens' relationship with patient Denny Duquette, which resulted in high critical acclaim and positive fan response.

The show ended its second season with 21.07 million total viewers and a 6.9 ratings share in the 18–49 demographic. The season opened to high critical acclaim, as most agreed on a significant improvement in storylines. The season saw numerous cast and crew members receive awards and nominations at ceremonies like the 58th Primetime Emmy Awards and the 64th Golden Globe Awards. Katherine Heigl and Chandra Wilson were the cast members with the most nominations for their portrayals of Izzie Stevens and Miranda Bailey, respectively. The series was chosen in the top 10 for several 2006 "best of television" lists, including USA Today, San Jose Mercury News, TV Guide, and Orlando Sentinel. The website Screen Rant ranked the season at number one on their 2023 ranking of the 19 Grey's Anatomy seasons that had aired at the time. Containing 27 episodes, out of which four were originally produced for the first season, it is the longest season to date.

Episodes

Each episode of this season is named after a song.

Cast and characters

Main Ellen Pompeo as Dr. Meredith Grey Sandra Oh as Dr. Cristina Yang Katherine Heigl as Dr. Izzie Stevens Justin Chambers as Dr. Alex Karev T. R. Knight as Dr. George O'Malley Chandra Wilson as Dr. Miranda Bailey James Pickens Jr. as Dr. Richard Webber Kate Walsh as Dr. Addison Montgomery-Shepherd Isaiah Washington as Dr. Preston Burke Patrick Dempsey as Dr. Derek Shepherd

Recurring Sara Ramirez as Dr. Callie Torres Brooke Smith as Dr. Erica Hahn Kate Burton as Ellis Grey Steven W. Bailey as Joe, the Bartender Chris O'Donnell as Finn Dandridge Loretta Devine as Adele Webber Jeffrey Dean Morgan as Denny Duquette

Notable guests

Eric Dane as Dr. Mark Sloan Sarah Utterback as Olivia Harper Kali Rocha as Sydney Heron Tsai Chin as Helen Yang Jeff Perry as Thatcher Grey Mare Winningham as Susan Grey Laurie Metcalf as Beatrice Carver Jillian Armenante as Mindy Carlson Brian Kerwin as Holden McKee Jesse Plemons as Jake Burton Tessa Thompson as Camille Travis Monica Keena as Bonnie Crasnoff Kym Whitley as Yvonne

Katherine LaNasa as Vera Kalpana Cress Williams as Tucker Jones Anjul Nigam as Dr. Raj Sen Robin Pearson Rose as Patricia Murphy George Dzundza as Harold O'Malley Tim Griffin as Ronny O'Malley Greg Pitts as Jerry O'Malley Mary Kay Place as Olive Warner Christina Ricci as Hannah Davies John Cho as Marshall Stone Mandy Siegfried as Molly Grey Kyle Chandler as Dylan Young

Production

Crew The season was produced by Touchstone Television in association with ShondaLand Production Company and The Mark Gordon Company. Shonda Rhimes returned as the series' showrunner and executive producer. She also continued her position from the first two seasons as one of the most prominent members of the writing staff. Betsy Beers, Mark Gordon, Mark Wilding, and Rob Corn returned as executive producers, along with James D. Parriott, Peter Horton, and Krista Vernoff, who have been in this position since the inception of the series. Parriott, who also served as an episodic writer, left the series at the conclusion of the season. Joan Rater and Tony Phelan continued to serve as co-executive producers, with Rater being a supervising producer as well. Stacy McKee, who would be promoted to co-executive producer for the third season, returned to the series as a producer and a member of the writing staff. Having written 3 episodes for the first season, Rhimes returned as a writer for 5 episodes. Parriott, Vernoff, Phelan, Rater, Wilding and Mimi Schmir were the most prominent members of the writing staff, with Parriott, Phelan, Rater, Wilding, Clack writing 2 episodes and Schmir producing the script for 3. Gabrielle Stanton and Harry Werksman, Jr. worked together for the writing of 2 episodes, after having written 1 episode for the series in the past.

The season includes the first episode to be written by Zoanne Clack, who would become one of the series' main writers, as well as a co-producer and executive story editor. Other writers include Kip Koenig, Blythe Robe and Elizabeth Klaviter. Executive producer Peter Horton returned to the series to direct 5 episodes for the season, after writing 2 episodes in the second season. Rob Corn directed 2 episodes, whereas Adam Davidson is credited for writing 3 episodes, his last ones in the series. Among the other directors are Wendey Stanzler, Mark Tinker, Jeff Melman, Jessica Yu, Lesli Linka Glatter, Michael Dinner, Dan Minahan, David Paymer, Julie Anne Robinson, Tricia Brock, and Seith Mann. Danny Lux continued his position as the main music composer for the series, while Herbert Davis, Tim Suhrstedt and Adam Kane served as the season's cinematography directors. Susan Vaill and Edward Ornelas resumed their positions as editors, joined by Briana London, who left the series after 9 episodes. Linda Lowy and John Brace, responsible for the casting since the beginning of the series, returned as casting team members. After the departure of Laurence Bennett, the production design team was taken over by Donald Lee Harris, with Amy B. Ancona and Brandee Dell'Aringa joining for 10 episodes each.

Writing and filming

The season was primarily filmed in Los Angeles, California. Fisher Plaza, which is the headquarters building for the media company Fisher Communications and Fisher's ABC affiliated Komo radio and television stations for Seattle, is used for some exterior shots of Seattle Grace Mercy West Hospital, such as air ambulances landing on the Komo Television newscopter's helipad. This puts Seattle Grace conveniently close to the Space Needle, which is directly across the street from Fisher Plaza, the Seattle Monorail, and other local landmarks. However, the hospital used for most other exterior and many interior shots is not in Seattle, are shot at the VA Sepulveda Ambulatory Care Center in North Hills, California. Most scenes are primarily taped in Los Feliz, Los Angeles, at the Prospect Studios, and the set occupies two stages, including the hospital pieces, but some outside scenes are shot at the Warren G. Magnuson Park in Seattle. Several props used are genuine medical supplies, including the MRI machine.

Prior to being cast, Sara Ramirez was seen by ABC executives, in her Broadway performance of Spamalot, which garnered their attention. Due to their admiration, the network offered Ramirez a role on any ABC television series, of her choice, which ultimately led in her choosing Grey's Anatomy. Ramirez further explained that at her initial audition, the producers liked her, and had intentions to add her to the show, but did not know whom to cast her as. She also said she was in awe of how the executives said, "Pick a show, any show!", a statement she deemed rare. Ramirez's character was given recurring status in the second season, having been conceived as a love-interest for George O'Malley. At Torres' initial appearance on the show, she was disliked by fans, due to her getting in the way of O'Malley and Grey's relationship. When asked of this, Ramirez said: "You do run across a lot of people who are extremely invested in that storyline. Obviously, I've heard some negative stuff."

Discussing Izzie Stevens' relationship with Alex Karev, Katherine Heigl described her character as naive enough to believe she can save him, assessing that: "Even when Alex was a complete dirtbag to her, she forgave him and gave him another chance. And he really screwed her over." Writer Stacy McKee described Izzie's moving on from Alex to patient Denny Duquette as "karma", as Alex previously treated Izzie badly, yet as he begins to realize his true feelings, he is forced to watch her embark on a romance with Denny, regarded by her as "undeniably handsome and totally charming." Series writer Blythe Robe commented on Izzie and Denny: "I love the way Izzie lights up when she’s around him. I love their relationship because it's so pure and honest and completely game-free." Writer Elizabeth Klaviter noted at this time the way Izzie "seems to be sacrificing her reputation because of her feelings for Denny." When Izzie deliberately worsened Denny's condition to move him up the transplant list, series writer Mark Wilding questioned the morality of the actions, asking: "Is Izzie bad for doing it? Is she tremendously irresponsible? She cut the wire for love so does that make her action understandable?" Series creator Shonda Rhimes discussed costuming choices in the scene which saw the interns gather around Denny's deathbed, explaining: "Meredith and Cristina and Alex and George and Callie are all dressed, not for a prom, but for a funeral. Everyone in dark colors, everyone dressed somberly. As if they were in mourning. Only Izzie is in happy pink. Only Izzie looks like she didn't know this was coming."