DeSalvo or De Salvo is an Italian surname. Notable people with the surname include:
People Albert DeSalvo (1931–1973), American serial killer known as the Boston Strangler Barbara De Salvo, electronics engineer Karen DeSalvo (born 1966), American federal official Louise DeSalvo (1942–2018), American writer and professor Matt DeSalvo (born 1980), American baseball player Roman De Salvo (born 1965), American artist and sculptor Russ DeSalvo, American songwriter, musician and record producer
Fictional characters Charlie DeSalvo, on the TV show Highlander: The Series
See also DiSalvo, a list of people with the surname DiSalvo or Di Salvo Salvo (surname)