HRB may refer to:
HRB (gene) HRB Systems, an American defense contractor Boeing HRB-1, a helicopter Croatian Revolutionary Brotherhood (Croatian: ) FBI Human Resources Branch, US H&R Block, NYSE symbol Harbin Taiping International Airport, Heilongjiang, China Health Research Board, Ireland House of Responsibility, in Hitler's birth house, Braunau am Inn, Germany HRB, a Rockwell scale of materials' hardness