Spen may refer to:
SPEN, human gene Spen, West Yorkshire, a location in England River Spen, river in West Yorkshire, England, the United Kingdom SS Spen, British steamship built in 1908 SP Energy Networks, the energy networks arm of Scottish Power
People Spen King (1925–2010), British automobile designer Spen Whittaker (1871–1910), English football manager
See also S Pen, stylus pen for Samsung smartphones