Wayne High School can refer to:
Wayne High School (Indiana) in Fort Wayne, Indiana Wayne High School (Nebraska) in Wayne, Nebraska Wayne High School (New York) in Ontario Center, New York Wayne High School (Ohio) in Huber Heights, Ohio Wayne High School (West Virginia) in Wayne, West Virginia Wayne High School (Utah) in Bicknell, Utah Wayne County High School (Georgia) in Jesup, Georgia Wayne County High School (Kentucky) in Monticello, Kentucky Wayne County High School (Mississippi) in Waynesboro, Mississippi Wayne Memorial High School in Wayne, Michigan