V16 may refer to:
Aircraft Fokker V.16, a German experimental aircraft Mil V-16, a Soviet helicopter McDonnell Douglas AV-16, a proposed ground-attack aircraft
Other uses Cadillac V-16, an American car V16 engine, a sixteen-cylinder engine V16 warning beacon lights V16, a grade in bouldering V16, a family history of malignant neoplasm, in the ICD-9 V codes Nissan V16, the name adopted in Chile for the Nissan Sentra