Manuel Perez may refer to:
Arts and entertainment Manuel Pérez y Curis (1884–1920), Uruguayan poet Manuel Perez (musician) (1871–1946), American cornetist and bandleader Manuel Perez (animator) (1914–1981), animator for Warner Bros. Cartoons Manuel Pérez (director) (1939–2025), Cuban film director Manuel "Manny" Pérez Batista or Manny Pérez (born 1969), Dominican actor
Politics Manuel Pérez (President of Nicaragua) (1800–1852), President of Nicaragua 1843–1844 Manuel Pérez (Lieutenant Governor of Upper Louisiana) (1735–1819), Lieutenant Governor of Upper Louisiana 1787–1792 Manuel Pérez Cárdenas (born 1953), Mexican economist and politician (1911–1985), Venezuelan politician, secretary-general of UNCTAD (born 1951), Spanish politician, mayor of Córdoba Manuel Pérez Treviño (1890–1945), Mexican revolutionary, politician and ambassador V. Manuel Perez (born 1973), U.S. politician, California State Assemblyman
Sports Manuel Pérez Benítez, better known as El Cordobés, Spanish matador of the 1960s Manu Pérez (born 1978), Spanish ski mountaineer Manuel Pérez (footballer, born 1980), Mexican football manager and former midfielder Manuel Pérez (boxer) (born 1984), Mexican-American professional boxer in the Lightweight division Manuel Perez (footballer, born 1991), French professional football midfielder for Grenoble Manuel Pérez (footballer, born 1993), Mexican football winger Manny Perez (soccer) (born 1999), American soccer player
Other Manuel Pérez García (born 1979), Spanish academic Manuel Pérez Jr. (1923–1945), American soldier and Medal of Honor recipient Manuel Pérez (teacher) (1890–1951), Puerto Rican teacher and public servant Manuel Pérez (guerrilla leader) (1943–1988), leader of the Colombian National Liberation Army from the 1970s to 1998