Signorelli is a surname. Notable people with the surname include:
Franco Signorelli (born 1991), Venezuelan footballer Frank Signorelli (1901–1975), American jazz pianist James Signorelli, American film director and cinematographer Luca Signorelli (c. 1445–1523), Italian Renaissance painter Marcelo Signorelli (born 1963), Italian-Uruguayan basketball player, coach, and author Maria Signorelli (1908–1992), Italian puppet master and collector Paolo Signorelli (politician) (1934–2010), Italian activist and politician Paolo Signorelli (footballer) (1939–2018), Italian footballer Pietro Napoli Signorelli (1731–1815), Italian scholar of classic literature Vincent Signorelli, American punk-rock drummer