Osornophryne (Osorno's toadlets or plump toads) is a genus of true toads endemic to the Cordillera Central in Colombia and central Andes in Ecuador.

Species Binomial name and author Common name Osornophryne antisana Napo plump toad Osornophryne backshalli Steve Backshall’s Andean Toad Osornophryne bufoniformis Peracca's plump toad Osornophryne cofanorum Osornophryne guacamayo Guacamayo plump toad Osornophryne occidentalis Osornophryne percrassa Herveo plump toad Osornophryne puruanta Osornophryne simpsoni Osornophryne sumacoensis Osornophryne talipes Cannatella's plump toad

Osornophryne angel, a species described in 2011, is considered a synonym of Osornophryne bufoniformis.

Distribution The genus occurs in Colombia (Antioquia Department) and the central Andes of Ecuador.

Description Osornophryne are small to medium sized toads. O. antisana is the smallest species, with a maximum snout-vent length of . O. puruanta is the largest species, with a maximum snout-vent length of . Species vary greatly in colour and texture. The toads are nocturnal, semiarboreal, and terrestrial.

The genus is characterised by hands and feet with thick webbing, a ventrally directed cloacal tube, and having five or six sacral vertebrae, amongst other characteristics. They lack vocal slits and a tympanic membrane. The head is usually wider than it is long.

The genus exhibits sexual dimorphism in various traits. The males have keratinized nuptial pads. The eggs are large, terrestrial, and unpigmented, with a dark brown capsule. The toads undergo direct development.

Etymology The genus is named after the professors Ernesto and Hernando Osorno Mesa.

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