James Wayne may refer to:
James M. Wayne (1790–1867), U.S. Supreme Court justice and U.S. representative SS James M. Wayne, a Liberty ship James Wayne (R&B musician) (1920–1978), American rhythm and blues musician who also recorded as James Waynes and "Wild Willie" Wayne Jimmy Wayne (born 1972), American country musician Jimmy Wayne (album) Jim Wayne, member of the Kentucky House of Representatives