Ruffo is a surname. Notable people with the surname include:
Noble house of Ruffo di Calabria Fabrizio Ruffo (1744–1827), Italian cardinal Fulco Ruffo di Calabria (1884–1946), Italian World War I flying ace Giordano Ruffo (1200-1256), Italian nobleman and early writer on equestrian medicine Paola Ruffo di Calabria (born 1937), queen consort of Belgium Tommaso Ruffo (1663–1753), Italian cardinal Polissena Ruffo (1400–1420), princess of Calabria
Others Albert J. Ruffo (1908–2003), American politician Andrée Ruffo, Canadian judge Antonio Ruffo (1610s–1678), Sicilian politician, nobleman, patron, and collector Armand Garnet Ruffo (born 1955), Canadian scholar, filmmaker, writer and poet Bruno Ruffo (1920–2007), Italian motorcycle road racer Dennis Ruffo, Canadian music promoter Ernesto Ruffo Appel (born 1952), American-born governor of Baja California John Ruffo (born 1954), American business executive Johnny Ruffo (1988–2023), Australian singer, songwriter, dancer, actor and television presenter Leonora Ruffo (1935–2007), Italian film actress Marco Ruffo, Italian architect Pietro Ruffo (born 1978), Italian artist Titta Ruffo (1877–1953), Italian baritone Victoria Ruffo (born 1962), Mexican actress Vincenzo Ruffo (c. 1508–1587), Italian composer of the Renaissance
See also Rufo (surname)