Ponziani is a surname. Notable people with this surname include:
Domenico Lorenzo Ponziani (1719–1796), Italian priest and chess player Antonella Ponziani (born 1964), Italian actress Frances of Rome (1384–1440), Italian Catholic mystic and saint, sometimes referred to as Francesca Bussa de' Ponziani after her marriage to Lorenzo Ponziani
See also Ponziani Opening, a chess opening named after Domenico Lorenzo Ponziani