Villacís or Villacis is a Hispanic surname. Notable people with the surname include:
Eduardo Villacis (born 1979), Major League Baseball pitcher Begoña Villacís (born 1977), Spanish politician Roberto de Villacis (born 1967), Ecuadorian American fashion designer Aníbal Villacís (1927–2012), Ecuadorian painter Belisario Villacís (1899–?), Ecuadorian long-distance runner