DiLorenzo is an Italian surname. Notable people with the surname include:
Francis X. DiLorenzo (1942–2017), American Roman Catholic bishop Daniel DiLorenzo, medical device entrepreneur and physician-scientist Thomas DiLorenzo, American economics professor Vincent Dilorenzo (1911–1989), English rugby league footballer who played in the 1930s and 1940s, and rugby union footballer who played in the 1940s Danielle DiLorenzo, a contestant of the American reality television show Survivor Laura DiLorenzo, co-protagonist of the 2007 homemade music video Chongalicious