R27 may refer to:
Missiles R-27 (air-to-air missile), a Soviet air-to-air missile R-27 Zyb, a Soviet submarine-launched ballistic missile
Roads R-27 regional road (Montenegro) R27 (South Africa)
Other uses R27 (New York City Subway car) BMW R27, a motorcycle HMA R.27, a rigid airship of the Royal Air Force , a destroyer of the Royal Navy R27: Very toxic in contact with skin, a risk phrase Renault R27, a Formula One racing car Rubik R-27 Kópé, a Hungarian training glider , a submarine of the United States Navy