LFR can refer to:
Lead-cooled fast reactor, a type of nuclear reactor LFR International, emergency medical service in Africa Lay First Responder Model, a model of emergency assistance implemented by LFR International Leavine Family Racing Lincolnshire Fire and Rescue Service in England Louisville Division of Fire, US Low-frequency radio range, an early radio navigation system A US Navy hull classification symbol: Inshore fire support ship (LFR) Leafs Fan Reaction, an internet series by Steve Dangle