C38 or C-38 may refer to:
Vehicles Aircraft Cessna C-38, an American civil utility aircraft Douglas C-38, an American military transport aircraft Gulfstream C-38A Courier, an American military transport aircraft
Ships , a C-class submarine of the Royal Navy
Surface vehicles Alfa Romeo Racing C38, an Italian Formula One car Carlsson C38, a German performance car New South Wales C38 class locomotive, an Australian steam locomotive
Other uses C-38 (cipher machine), an American mechanical cipher machine C-38 (Michigan county highway) C38 road (Namibia) Bill C-38, various legislation of the Parliament of Canada Caldwell 38, a spiral galaxy Heart cancer King's Gambit, a chess opening C-38 Canal, a straightened channel of the Kissimmee River