SM1 may refer to:
SM-1, a nuclear reactor SM1, a postcode district within the SM postcode area, in Sutton, Greater London Signalman First Class, a former rating in the U.S. Navy A surface-to-air missile, RIM-66 Standard (SM-1MR) or RIM-67 Standard (SM-1ER) VR Class Sm1, a type of train operated by the VR Group Spider-Man, the first film in the Spider-Man film series Scary Movie, the first film in the Scary Movie series Superman, the first Superman film SM1, Secondary Math 1 SM1, an entry index for individual medley events in disability swimming, see S1 (classification) SM-1, developmental code name for diphenhydramine/lorazepam/zolpidem, a combination sleep drug