APFA may refer to:
American Professional Football Association, later the National Football League, a professional American football league that operated during 1920–1921 American Professional Football Association, later the Midwest Football League (1935–1940), a minor professional American football league Association of Professional Financial Advisers, a trade association made up of financial advisers across the United Kingdom Association of Professional Flight Attendants, a transportation trade union in the United States Association for the Protection of Fur-Bearing Animals, an animal welfare organization based in Canada
See also Professional Footballers Australia, or PFA, sometimes mistakenly referred to as APFA AFPA (disambiguation)