A74 or A-74 may refer to:
A74 road, a major road in the UK A74(M) and M74 motorways, another road in the UK that largely replaced the original A74 Benoni Defense, in the Encyclopaedia of Chess Openings HLA-A74, an HLA-A serotype Iceberg A-74, an iceberg calved from the Antarctic Brunt Ice Shelf in February 2021