Simonelli is an Italian surname. Notable people with the surname include:
Alberto Simonelli (born 1967), Italian Paralympic archer Damon Simonelli (1959–2004), American planetary scientist Giorgio Simonelli (1901–1966), Italian film director, editor, screenwriter and journalist Giovanni Simonelli (born 1952), Italian football manager Giuseppe Simonelli (c. 1650–1710), Italian Baroque painter Pasquale Simonelli (1878–1960), Italian-American banker Virginio Simonelli (born 1985), Italian singer Vittorio Simonelli (1860–1929), Italian geologist and paleontologist
See also 8071 Simonelli, a main-belt asteroid