MDHS can refer to any of the following:

High schools Markham District High School, Markham, Ontario, Canada Mater Dei High School (disambiguation) Medical District High School, Memphis, Tennessee, USA Monsignor Donovan High School, Toms River, New Jersey, USA Mount Douglas High School, Saanich, British Columbia, Canada Milton District High School, Milton, Ontario, Canada Myungduk High School, Gangseo District, Seoul, South Korea

Other MDHS100, a standard for Surveying, sampling and assessment of asbestos containing materials produced by the UK Health and Safety Laboratory Majlis Daerah Hulu Selangor, a local authority in Kuala Kubu Bharu in Malaysia Maryland Historical Society, abbreviated as "MdHS" The University of Melbourne Faculty of Medicine, Dentistry and Health Sciences Mississippi Department of Human Services MDHS, the Delhi Metro station code for Mandi House metro station, New Delhi, India