UCO may refer to:
Organizations Central Operative Unit (Spanish: Unidad Central Operativa), a special unit of the Civil Guard of Spain UCO Bank, formerly United Commercial Bank
Education University of Central Oklahoma, Edmond, Oklahoma, US University of California Observatories, a multi-campus astronomical research unit of the University of California, US University of Colorado system (officially uses the acronym CU) Catholic University of the West (Université catholique de l'Ouest), Angers, France Universidad Católica de Oriente, Antioquia, Colombia
Other uses UCO, female vocalist of the Japanese band Funta Unequal crossing over, a DNA mutation mechanism Used cooking oil