Chromosome 14 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 14 spans about 107 million base pairs (the building material of DNA) and represents between 3 and 3.5% of the total DNA in cells.
The centromere of chromosome 14 is positioned approximately at position 17.2 Mbp.
Genes Number of genes The following are some of the gene count estimates of human chromosome 14. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). Among various projects, the collaborative consensus coding sequence project (CCDS) takes an extremely conservative strategy. So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes.
Estimated by Protein-coding genes Non-coding RNA genes Pseudogenes Source Release date CCDS 583 — — 2016-09-08 HGNC 593 324 513 2017-05-12 Ensembl 820 856 518 2017-03-29 UniProt 720 — — 2018-02-28 NCBI 621 690 598 2017-05-19
Gene list
The following is a partial list of genes on human chromosome 14. For complete list, see the link in the infobox on the right.
Diseases and disorders The following diseases are some of those related to genes on chromosome 14:
Alpha-1 antitrypsin deficiency Alzheimer's disease Burkitt's lymphoma (t8;14) congenital hypothyroidism dopamine-responsive dystonia Follicular lymphoma (t14;18) FOXG1 syndrome Hypertrophic cardiomyopathy Krabbe disease Cranio-lenticulo-sutural dysplasia Machado-Joseph disease Mosaic monosomy 14 Multiple myeloma Niemann-Pick disease Nonsyndromic deafness Sensenbrenner syndrome Tetrahydrobiopterin deficiency Kagami-Ogata Syndrome Temple Syndrome Oculopharyngeal muscular dystrophy
Cytogenetic band
+ G-bands of human chromosome 14 in resolution 850 bphsGenome Decoration Page, NCBI. Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). Last update 2014-06-03. Retrieved 2017-04-26. Chr. Arm"p": Short arm; "q": Long arm. BandFor cytogenetic banding nomenclature, see article locus. ISCNstartThese values (ISCN start/stop) are based on the length of bands/ideograms from the ISCN book, An International System for Human Cytogenetic Nomenclature (2013). Arbitrary unit. ISCNstop Basepairstart Basepairstop Staingpos: Region which is positively stained by G banding, generally AT-rich and gene poor; gneg: Region which is negatively stained by G banding, generally CG-rich and gene rich; acen Centromere. var: Variable region; stalk: Stalk. Density 14 p 13 0 284 gvar 14 p 12 284 624 stalk 14 p 11.2 624 1249 gvar 14 p 11.1 1249 1433 acen 14 q 11.1 1433 1660 acen 14 q 11.2 1660 2043 gneg 14 q 12 2043 2313 gpos 100 14 q 13.1 2313 2469 gneg 14 q 13.2 2469 2582 gpos 50 14 q 13.3 2582 2724 gneg 14 q 21.1 2724 2923 gpos 100 14 q 21.2 2923 3008 gneg 14 q 21.3 3008 3264 gpos 100 14 q 22.1 3264 3491 gneg 14 q 22.2 3491 3604 gpos 25 14 q 22.3 3604 3718 gneg 14 q 23.1 3718 3916 gpos 75 14 q 23.2 3916 4044 gneg 14 q 23.3 4044 4186 gpos 50 14 q 24.1 4186 4484 gneg 14 q 24.2 4484 4626 gpos 50 14 q 24.3 4626 4839 gneg 14 q 31.1 4839 5051 gpos 100 14 q 31.2 5051 5094 gneg 14 q 31.3 5094 5349 gpos 100 14 q 32.11 5349 5406 gneg 14 q 32.12 5406 5505 gpos 25 14 q 32.13 5505 5619 gneg 14 q 32.2 5619 5732 gpos 50 14 q 32.31 5732 5903 gneg 14 q 32.32 5903 6016 gpos 50 14 q 32.33 6016 6300 gneg
References
External links