Chromosome 3 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 3 spans more than 201 million base pairs (the building material of DNA) and represents about 6.5 percent of the total DNA in cells.
Genes Number of genes The following are some of the gene count estimates of human chromosome 3. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). Among various projects, the collaborative consensus coding sequence project (CCDS) takes an extremely conservative strategy. So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes.
Estimated by Protein-coding genes Non-coding RNA genes Pseudogenes Source Release date CCDS 1,024 — — 2016-09-08 HGNC 1,036 483 761 2017-05-12 Ensembl 1,073 1,158 761 2017-03-29 UniProt 1,081 — — 2018-02-28 NCBI 1,085 1,108 902 2017-05-19
List of genes
The following is a partial list of genes on human chromosome 3. For complete list, see the link in the infobox on the right.
p-arm Partial list of the genes located on p-arm (short arm) of human chromosome 3:
q-arm Partial list of the genes located on q-arm (long arm) of human chromosome 3:
Diseases and disorders
The following diseases and disorders are some of those related to genes on chromosome 3:
3-Methylcrotonyl-CoA carboxylase deficiency 3q29 microdeletion syndrome Acute myeloid leukemia (AML) Alkaptonuria Arrhythmogenic right ventricular dysplasia Atransferrinemia Autism Autosomal dominant optic atrophy ADOA plus syndrome Biotinidase deficiency Blepharophimosis, epicanthus inversus and ptosis type 1 Breast/colon/lung/pancreatic cancer Brugada syndrome Castillo fever Carnitine-acylcarnitine translocase deficiency Cataracts Cerebral cavernous malformation Charcot–Marie–Tooth disease, type 2 Charcot–Marie–Tooth disease Chromosome 3q duplication syndrome Coproporphyria A location on human chromosome 3 is associated with respiratory failure and possibly with increased severity in COVID-19 Dandy–Walker syndrome Deafness Diabetes Dystrophic epidermolysis bullosa Endplate acetylcholinesterase deficiency Essential tremors Ectrodactyly, Case 4 Glaucoma, primary open angle Glycogen storage disease Hailey–Hailey disease Harderoporphyrinuria Heart block, progressive/nonprogressive Hereditary coproporphyria Hereditary nonpolyposis colorectal cancer HIV infection, susceptibility/resistance to Hypobetalipoproteinemia, familial Hypothermia Leukoencephalopathy with vanishing white matter Long QT syndrome Lymphomas Malignant hyperthermia susceptibility Metaphyseal chondrodysplasia, Murk Jansen type Microcoria Möbius syndrome Moyamoya disease Mucopolysaccharidosis Muir–Torre family cancer syndrome Myotonic dystrophy Neuropathy, hereditary motor and sensory, Okinawa type Night blindness Nonsyndromic deafness Ovarian cancer Porphyria Propionic acidemia Protein S deficiency Pseudocholinesterase deficiency Pseudo-Zellweger syndrome Retinitis pigmentosa Romano–Ward syndrome Seckel syndrome Sensenbrenner syndrome Septo-optic dysplasia Short stature Spinocerebellar ataxia Sucrose intolerance T-cell leukemia translocation altered gene Usher syndrome von Hippel–Lindau syndrome Waardenburg syndrome Xeroderma pigmentosum, complementation group c
Cytogenetic band
+ G-bands of human chromosome 3 in resolution 850 bphs Chr. Arm"p": Short arm; "q": Long arm. BandFor cytogenetic banding nomenclature, see article locus. ISCNstartThese values (ISCN start/stop) are based on the length of bands/ideograms from the ISCN book, An International System for Human Cytogenetic Nomenclature (2013). Arbitrary unit. ISCNstop Basepairstart Basepairstop Staingpos: Region which is positively stained by G banding, generally AT-rich and gene poor; gneg: Region which is negatively stained by G banding, generally CG-rich and gene rich; acen Centromere. var: Variable region; stalk: Stalk. Density 3 p 26.3 0 175 gpos 50 3 p 26.2 175 263 gneg 3 p 26.1 263 408 gpos 50 3 p 25.3 408 642 gneg 3 p 25.2 642 759 gpos 25 3 p 25.1 759 963 gneg 3 p 24.3 963 1269 gpos 100 3 p 24.2 1269 1357 gneg 3 p 24.1 1357 1561 gpos 75 3 p 23 1561 1751 gneg 3 p 22.3 1751 1926 gpos 50 3 p 22.2 1926 2013 gneg 3 p 22.1 2013 2188 gpos 75 3 p 21.33 2188 2451 gneg 3 p 21.32 2451 2626 gpos 50 3 p 21.31 2626 3239 gneg 3 p 21.2 3239 3385 gpos 25 3 p 21.1 3385 3676 gneg 3 p 14.3 3676 3910 gpos 50 3 p 14.2 3910 4143 gneg 3 p 14.1 4143 4362 gpos 50 3 p 13 4362 4566 gneg 3 p 12.3 4566 4814 gpos 75 3 p 12.2 4814 4946 gneg 3 p 12.1 4946 5077 gpos 75 3 p 11.2 5077 5135 gneg 3 p 11.1 5135 5266 acen 3 q 11.1 5266 5427 acen 3 q 11.2 5427 5602 gvar 3 q 12.1 5602 5762 gneg 3 q 12.2 5762 5850 gpos 25 3 q 12.3 5850 5996 gneg 3 q 13.11 5996 6229 gpos 75 3 q 13.12 6229 6361 gneg 3 q 13.13 6361 6594 gpos 50 3 q 13.2 6594 6682 gneg 3 q 13.31 6682 6871 gpos 75 3 q 13.32 6871 6973 gneg 3 q 13.33 6973 7148 gpos 75 3 q 21.1 7148 7294 gneg 3 q 21.2 7294 7440 gpos 25 3 q 21.3 7440 7674 gneg 3 q 22.1 7674 7936 gpos 25 3 q 22.2 7936 8053 gneg 3 q 22.3 8053 8228 gpos 25 3 q 23 8228 8461 gneg 3 q 24 8461 8811 gpos 100 3 q 25.1 8811 9001 gneg 3 q 25.2 9001 9162 gpos 50 3 q 25.31 9162 9264 gneg 3 q 25.32 9264 9366 gpos 50 3 q 25.33 9366 9453 gneg 3 q 26.1 9453 9803 gpos 100 3 q 26.2 9803 9949 gneg 3 q 26.31 9949 10183 gpos 75 3 q 26.32 10183 10329 gneg 3 q 26.33 10329 10489 gpos 75 3 q 27.1 10489 10620 gneg 3 q 27.2 10620 10737 gpos 25 3 q 27.3 10737 10883 gneg 3 q 28 10883 11175 gpos 75 3 q 29 11175 11700 gneg
See also Coiled-coil domain-containing 37 (FLJ40083) RTP3 (gene)
References
External links