Isabella is an unincorporated community in Ozark County, Missouri, United States. It is located approximately thirteen miles west of Gainesville and two miles east of Theodosia and Bull Shoals Lake along U.S. Highway 160.Ava, Missouri, 30x60 Minute Topographic Quad, USGS, 2002 Isabella has a post office with the ZIP code 65676.Ozark County Post Offices

A post office called Isabella has been in operation since 1856. An early postmaster gave the community the name of his daughter, Isabella Brattin.

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