ENC may refer to:
Eastern Naval Command of the Indian Navy Eastern Nazarene College in Quincy, Massachusetts Eastern North Carolina Effective nuclear charge Effective number of codons Electronic navigational chart En language ENC (company), a bus manufacturer previously known as ElDorado National–California ENC Press, an American publishing company Encapsulin, a protein family Enfield Chase railway station, in London Equality North Carolina, an American LGBT advocacy group Escuela Nacional de Cine, a film school in Caracas, Venezuela European Nations' Cup (disambiguation) Nancy-Essey Airport, in France