Tuco may refer to:
People and fictional characters El Tuco, Mauricio Alfaro (born 1956), Salvadoran footballer and coach Tuco Ramirez, a character played by Eli Wallach in the 1966 Italian film The Good, the Bad and the Ugly Tuco Salamanca, a character played by Raymond Cruz in the Breaking Bad franchise Tuco, Ariel Ngueukam, Cameroonian footballer
Other Tuco (mountain), a summit in the mountain range Cordillera Blanca, Peru
See also Tuco-tuco, a species of South American rodent