Lorenzetti is an Italian surname. Notable people with the surname include:
Ambrogio Lorenzetti ( 1290–1348), Sienese painter Angelo Lorenzetti (born 1964), Italian volleyball coach Daniel Lorenzetti, author, documentary photographer, and explorer Dario Lorenzetti (1970–2012), American military officer and intelligence operative Enrico Lorenzetti (1911–1989), Italian motorcycle road racer Gustavo Lorenzetti (born 1985), Argentine footballer Maria Rita Lorenzetti (born 1953), Italian politician Pietro Lorenzetti ( 1280–1348), Sienese painter, brother of Ambrogio Lorenzetti Ricardo Lorenzetti (born 1955), Argentine judge Tommaso Lorenzetti (born 1985), Italian motorcycle racer