DME may refer to:
Chemicals DME (psychedelic), 3,4-dimethoxy-beta-hydroxyphenethylamine, a psychedelic drug Dimethoxyethane, a solvent Dimethylethanolamine, a precursor molecule for C-choline Dimethyl ether, a fuel and an aerosol spray propellant
Medicine Diabetic macular edema Durable medical equipment
Technology Dashtop mobile equipment Diastatic malt extract, used in home-brewing Distance measuring equipment, used in aviation Dropping mercury electrode, used in polarography ICL Direct Machine Environment, an operating system
Transport Delhi–Mumbai Expressway, in India Dakota, Minnesota and Eastern Railroad Disney's Magical Express, at Walt Disney World Moscow Domodedovo Airport, serving Moscow, Russia
Other uses Design Management Europe Award DME Academy, in Daytona Beach, Florida Dubai Mercantile Exchange Ɗugwor language United States District Court for the District of Maine Durium Marche Estere, a sub-label of Durium Records