Frenzel is a German surname that originated in the Rhineland, and today is prevalent among Volga Germans and in east-central Germany, focused on Dresden. It is a patronymic name meaning son of Franciscus. Notable people with the surname include:

Alfred Frenzel (1899–1968), Czech spy of the Cold War era Bill Frenzel (1947–2014), American politician Eric Frenzel (born 1988), German skier Johannes Frenzel (1858–1897), German biologist Karl Frenzel (1911–1996), German Nazi SS-Oberscharführer Michael Frenzel (born 1947), German business executive Oskar Frenzel (1855–1915), German animal and landscape painter Salomon Frenzel von Friedenthal (1560/64–1600), Silesian writer

See also Curt Frenzel Stadium

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