Shadrin (masculine, ) or Shadrina (feminine, ) is a Russian surname. Notable people with the surname include:
Aleksandr Shadrin (1988–2014), Uzbekistani soccer player Andrei Shadrin, Cossack leader in 16th century Elena Shadrina (born 1982), Russian weightlifter Nicholas Shadrin (1922–1975), Soviet naval officer and defector Pavel Shadrin (born 1993), Russian soccer player Tatiana Shadrina (born 1974), Russian chess player Vladimir Shadrin (1948–2021), Soviet ice hockey player