Jessel or Jessell is a surname. Notable people with the surname include:
Sir Charles Jessel, (1860–1928), baronet, British barrister, magistrate and businessman Jesselton, now Kota Kinabalu, Sabah, Malaysia David Jessel, British journalist George Jessel: George Jessel (actor) (1898–1981), American vaudevillian George Jessel (jurist) (1824–1883), British jurist Herbert Jessel, 1st Baron Jessel (1866–1950), British soldier and politician Kenneth A. Jessell, educator and 6th President of Florida International University Leon Jessel, German composer Patricia Jessel, actress Ray Jessel (1929–2015), American-Welsh composer Stephen Jessel (1943–2025), British correspondent Thomas Jessell, scientist Toby Jessel, British politician
Fictional people Miss Jessel, a character in Henry James's The Turn of the Screw and its adaptations