O'Brian is an Irish surname and may refer to:
People named O'Brian Forename O'Brian White (born 1985), Jamaican footballer O'Brian Woodbine (born 1988), Jamaican footballer
Surname Conor O'Brian (born 1980), a ring name of American professional wrestler Ryan Parmeter Hugh O'Brian (1925–2016), stage name of American actor Hugh Krampe Jack O'Brian (1914–2000), columnist and supporter of Joseph McCarthy Katy O'Brian (born 1989), American actress Michael John O'Brian (1928–2002), Pakistan Air Force air vice-marshal Patrick O'Brian (1914–2000), pen name of British novelist and translator Richard Russ Peter O'Brian (actor) (born 1956), New Zealand/Indonesian actor Peter O'Brian (film producer) (born 1947), Canadian film producer
Fictional people named O'Brian Chloe O'Brian, a character in the American TV series 24 Morris O'Brian, a character in the American TV series 24
See also O'Brien (surname), alternate Anglicization of surname (also O'Bryan) Dara Ó Briain, Irish comedian and presenter