Santo Tomé (Spanish for Saint Thomas) may refer to the following places:
Argentina Santo Tomé, Corrientes, a city in the province of Corrientes Santo Tomé Department, a department in the province of Corrientes Santo Tomé, Santa Fe, a city in the province of Santa Fe
Spain Santo Tomé, Jaén, a municipality in the province of Jaén, in the autonomous community of Andalusia Santo Tomé del Puerto, a municipality in the province of Segovia, in the autonomous community of Castile and León Santo Tomé de Zabarcos, a municipality in the province of Ávila, in the autonomous community of Castile and León
Venezuela Santo Tomé de Guayana de Angostura del Orinoco, the former name of Ciudad Bolívar
See also São Tomé (disambiguation)