São Tomé is the capital of São Tomé and Príncipe.

São Tomé (Portuguese for Saint Thomas) may also refer to:

Places

Brazil São Tomé, Paraná São Tomé, Rio Grande do Norte São Thomé das Letras, a touristic town in Minas Gerais India Chennai, known as São Tomé when under Portuguese control Portugal São Tomé de Abação, a parish in the municipality of Guimarães São Tomé and Príncipe São Tomé (island), an island in São Tomé and Príncipe