Desaguadero may refer to:
Rivers Desaguadero River (Argentina), a river in Argentina, also known as Río Salado Desaguadero River (Bolivia and Peru), a river originated in Lake Titicaca in the border of Peru and Bolivia
Places Desaguadero, Argentina Desaguadero, Bolivia-Peru, the capital town of Desaguadero District, Chucuito Province, Puno Department, Peru Desaguadero District, in Chucuito Province, Puno Department, Peru Desaguadero (La Paz), a village in Desaguadero Municipality, Ingavi Province, La Paz Department, Bolivia Desaguadero Municipality, in Ingavi Province, La Paz Department, Bolivia