Sean O'Brien may refer to:
Sportspeople Seán O'Brien (Gaelic footballer), Gaelic footballer for Nemo Rangers Seán O'Brien (Cork hurler) (1926–?), Irish hurler Seán O'Brien (Tipperary hurler), Irish hurler Sean O'Brien (ice hockey) (born 1972), American former ice hockey left winger Seán O'Brien (rugby union, born 1987), former Irish rugby union international flanker for Leinster and London Irish Seán O'Brien (rugby union, born 1994), former Irish rugby union flanker for Connacht Seán O'Brien (rugby union, born 1998), Irish rugby union centre / winger for Munster Seán O'Brien (rugby union, born 2000), American-born Irish rugby union flanker for Connacht Sean O'Brien (windsurfer) (born 1984), Australian windsurfer Sean O'Brien (footballer), English footballer
Other people Sean O'Brien (writer) (born 1952), British writer Sean C. O'Brien, co-discoverer of buckminsterfullerene Sean O'Brien (labor leader), American trade unionist Sean O'Brien (musician), bassist and original member of Boston rock band Come Sean O'Brien (politician) (born 1969), Democratic member of the Ohio Senate
See also John O'Brien (disambiguation) Sean O'Bryan (born 1963), American actor Shaun O'Brien (disambiguation)