The Sacrifice of Isaac refers to the Binding of Isaac, a story from the Hebrew Bible found in Genesis 22.

The Sacrifice of Isaac may also refer to: Sacrifice of Isaac (Andrea del Sarto), three paintings of c. 1527–1530 by Andrea del Sarto Abraham and Isaac (Titian), a painting of c. 1543–1544 by Titian, also called the Sacrifice of Isaac Sacrifice of Isaac (Caravaggio), two paintings of c. 1598–1603 by Caravaggio The Sacrifice of Isaac (Rembrandt), a painting of 1635 by Rembrandt Abraham's Sacrifice of Isaac (Bencovich), a painting of 1715 by Federico Bencovich

See also Abraham and Isaac (disambiguation) Sacrifice of Abraham (disambiguation)