Thomas Wake may refer to:
Thomas Wake, 2nd Baron Wake of Liddell (1297–1349) Thomas Wake (MP) for Northamptonshire (UK Parliament constituency) Thomas Wake (pirate), a late 17th-century privateer and pirate A fictional character played by Willem Dafoe in the 2019 film The Lighthouse
See also Thomas Wakeman (1846–1886), a Native American who organized the first Sioux Indian YMCA Thomas Wakefeld (died 1575), an English academic Wake (surname)