Spanier means "man from Spain" in German and, as a surname, may refer to:
Edwin Henry Spanier (1921–1996), American mathematician known for the Alexander-Spanier cohomology theory Graham Spanier (born 1948), former president of Penn State University Muggsy Spanier (1906–1967), American jazz musician Sam Spanier (1925–2008), American artist Wolfgang Spanier (1943–2018), German politician, member of the Bundestag Nicolina Dijjers Spanier (born 1909), real name of screen actress Lien Deyers Ian Spanier (born 1974), American Photographer