Duffell is a surname. Notable people with this surname include:
Charlie Duffell (born 1986), English cricketer Ian Duffell (born 20th century), English businessman Joseph Duffell (c.1862–1936), English-born Australian politician Peter Duffell (1922–2017), British film and TV director and screenwriter Peter Duffell (British Army officer), (born 1939), Commander of British forces in Hong Kong
See also Albert Duffel (1813–1862), American justice