William Keane may refer to:
William Keane (author), 19th-century English garden writer William Keane (bishop) RC bishop of Ross then Cloyne, Ireland William Keane (sailor) (1899–1949), American Olympic sailor Will Keane (born 1993), Irish football player Bill Keane (footballer) (1900–1978), Australian rules footballer Bil Keane (1922–2011), creator of The Family Circus comic Billy Keane (fl. 1980s), Irish hurler
See also William Kean (1871–1954), British trade unionist William Keene (1915–1992), American television actor William B. Keene (1925–2018), American attorney, judge and television judge William Keen (disambiguation)