YSC may refer to:

Acronyms and initialisms Yemeni Super Cup Yerevan Komitas State Conservatory a conservatory located in Yerevan, Armenia Yugoslav Super Cup Young Survival Coalition an international group for women under 40 who have been diagnosed with breast cancer Youth detention center#Youth Services Center the District of Columbia's secure juvenile detention center

Codes Sherbrooke Airport has IATA code YSC Jassic dialect has ISO 639-3 code ysc