The Honda CL125 was a scrambler motorcycle made by Honda from 1967 to 1974. Two different engines were used through the models life: 1967-1969: CL125A 124cc 2 cylinder 4-stroke, 1973-1974: CL125S 122cc 1 cylinder 4-stroke.

The CL125A was produced from 1967 to 1969 with a 124 cc 4-stroke engine and four-speed transmission. It was the smallest OHC twin cylinder four-stroke that Honda made, and was the smaller sibling to the 160, 175, 350 & 450 models.

In 1970, Honda introduced a 99 cc OHC single-cylinder four-stroke engine that was subsequently used in several CB, CL, and SL models. In 1973, Honda introduced the CL125S with a 122 cc version of this engine.

The CL125S was closely related to the CL100 produced from 1970 to 1973. The CL125S differed in that it had lower final-drive gearing, different tires, a shorter front fender, a braced handlebar, a high-mounted exhaust, and it lacked a tachometer. The CL125S had a reported dry weight of 196 lb (89 kg).