Prairie River may refer to:
Rivers in the United States
Prairie River, in Louisiana, a tributary of Bayou Pierre Prairie River (Michigan), a tributary of the St. Joseph River Prairie River (Big Sandy Lake), in Minnesota Prairie River (Mississippi River tributary), in Minnesota Prairie River (Wisconsin), a tributary of the Wisconsin River
Other uses Prairie River, Saskatchewan, Canada, a hamlet Prairie River station, now Prairie River Museum Prairie River, an Intel ASIC for the Omni-Path architecture
See also Long Prairie River, a tributary of the Crow Wing River in Minnesota, US Prairie Rivers Network, an American nonprofit organization Rivière des Prairies, a delta channel of the Ottawa River in Quebec, Canada